ZP2 gene

zona pellucida glycoprotein 2

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed of three glycoproteins with various functions during fertilization and preimplantation development. The glycosylated mature peptide is one of the structural components of the zona pellucida and functions in secondary binding and penetration of acrosome-reacted spermatozoa. Female mice lacking this gene do not form a stable zona matrix and are sterile. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

From UniProt:

Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy (PubMed:29895852). The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor (PubMed:29895852).

From NCBI Gene:

  • OOCYTE MATURATION DEFECT 6

From UniProt:

Oocyte maturation defect 6 (OOMD6): An autosomal recessive infertility disorder characterized by oocyte fertilization failure, due to defective sperm-binding to an abnormally thin zona pellucida in patient oocytes. [MIM:618353]

Cytogenetic Location: 16p12.3-p12.2, which is the short (p) arm of chromosome 16 between positions 12.3 and 12.2

Molecular Location: base pairs 21,197,450 to 21,214,510 on chromosome 16 (Homo sapiens Updated Annotation Release 109.20200522, GRCh38.p13) (NCBI)

Cytogenetic Location: 16p12.3-p12.2, which is the short (p) arm of chromosome 16 between positions 12.3 and 12.2
  • OOMD6
  • Zp-2
  • ZPA