ZP1 gene

zona pellucida glycoprotein 1

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene ensures the structural integrity of the zona pellucida. Mutations in this gene are a cause of oocyte maturation defect and infertility. [provided by RefSeq, May 2014]

From UniProt:

The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP1 ensures the structural integrity of the zona pellucida.

From NCBI Gene:

  • Oocyte maturation defect 1

From UniProt:

Oocyte maturation defect 1 (OOMD1): An infertility disorder caused by defective oocyte maturation that results in abnormal eggs lacking a zona pellucida. Affected females have normal menstrual cycles and sex hormone levels, no obstruction in the fallopian tubes or abnormalities of the uterus or adnexa. [MIM:615774]

Cytogenetic Location: 11q12.2, which is the long (q) arm of chromosome 11 at position 12.2

Molecular Location: base pairs 60,867,542 to 60,875,693 on chromosome 11 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 11q12.2, which is the long (q) arm of chromosome 11 at position 12.2
  • HEL163
  • OOMD
  • OOMD1