ZMYND15 gene

zinc finger MYND-type containing 15

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a MYND-containing zinc-binding protein with a nuclear localization sequence. A similar gene in mice has been shown to act as a testis-specific transcriptional repressor by recruiting histone deacetylase enzymes to regulate spatiotemporal expression of many haploid genes. This protein may play an important role in spermatogenesis. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jun 2012]

From UniProt:

Acts as a transcriptional repressor through interaction with histone deacetylases (HDACs). May be important for spermiogenesis.

From NCBI Gene:

  • Spermatogenic failure 14

From UniProt:

Spermatogenic failure 14 (SPGF14): A disorder resulting in the absence (azoospermia) or reduction (oligozoospermia) of sperm in the semen, leading to male infertility. [MIM:615842]

Cytogenetic Location: 17p13.2, which is the short (p) arm of chromosome 17 at position 13.2

Molecular Location: base pairs 4,740,015 to 4,746,119 on chromosome 17 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 17p13.2, which is the short (p) arm of chromosome 17 at position 13.2
  • SPGF14