ZMYND11 gene

zinc finger MYND-type containing 11

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The protein encoded by this gene was first identified by its ability to bind the adenovirus E1A protein. The protein localizes to the nucleus. It functions as a transcriptional repressor, and expression of E1A inhibits this repression. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

From UniProt:

Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2) (By similarity). Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage. Acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth.

From NCBI Gene:

  • Mental retardation, autosomal dominant 30

From UniProt:

Mental retardation, autosomal dominant 30 (MRD30): A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRD30 patients manifest mild intellectual disability and subtle facial dysmorphisms, including hypertelorism, ptosis, and a wide mouth. [MIM:616083]

A chromosomal aberration involving ZMYND11 is a cause of acute poorly differentiated myeloid leukemia. Translocation (10;17)(p15;q21) with MBTD1.

Cytogenetic Location: 10p15.3, which is the short (p) arm of chromosome 10 at position 15.3

Molecular Location: base pairs 134,340 to 254,637 on chromosome 10 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 10p15.3, which is the short (p) arm of chromosome 10 at position 15.3
  • BRAM1
  • BS69
  • MRD30