ZMIZ1 gene

zinc finger MIZ-type containing 1

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a member of the PIAS (protein inhibitor of activated STAT) family of proteins. The encoded protein regulates the activity of various transcription factors, including the androgen receptor, Smad3/4, and p53. The encoded protein may also play a role in sumoylation. A translocation between this locus on chromosome 10 and the protein tyrosine kinase ABL1 locus on chromosome 9 has been associated with acute lymphoblastic leukemia. [provided by RefSeq, Mar 2010]

From UniProt:

Acts as transcriptional coactivator. Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation (PubMed:14609956, PubMed:26522984). Also functions as a transcriptional coactivator in the TGF-beta signaling pathway by increasing the activity of the SMAD3/SMAD4 transcriptional complex (PubMed:16777850). Involved in transcriptional activation of a subset of NOTCH1 target genes including MYC. Involved in thymocyte and T cell development (By similarity).

From NCBI Gene:

  • NEURODEVELOPMENTAL DISORDER WITH DYSMORPHIC FACIES AND DISTAL SKELETAL ANOMALIES

Cytogenetic Location: 10q22.3, which is the long (q) arm of chromosome 10 at position 22.3

Molecular Location: base pairs 79,068,966 to 79,316,519 on chromosome 10 (Homo sapiens Updated Annotation Release 109.20191205, GRCh38.p13) (NCBI)

Cytogenetic Location: 10q22.3, which is the long (q) arm of chromosome 10 at position 22.3
  • MIZ
  • NEDDFSA
  • RAI17
  • TRAFIP10
  • ZIMP10