ZDHHC9 gene

zinc finger DHHC-type containing 9

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes an integral membrane protein that is a member of the zinc finger DHHC domain-containing protein family. The encoded protein forms a complex with golgin subfamily A member 7 and functions as a palmitoyltransferase. This protein specifically palmitoylates HRAS and NRAS. Mutations in this gene are associated with X-linked mental retardation. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, May 2010]

From UniProt:

The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS.

From NCBI Gene:

  • Mental retardation, X-linked, syndromic, raymond type

From UniProt:

Mental retardation, X-linked, syndromic, ZDHHC9-related (MRXSZ): A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Some MRXSZ patients have marfanoid habitus as an additional feature. [MIM:300799]

Cytogenetic Location: Xq26.1, which is the long (q) arm of the X chromosome at position 26.1

Molecular Location: base pairs 129,803,288 to 129,843,934 on the X chromosome (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: Xq26.1, which is the long (q) arm of the X chromosome at position 26.1
  • CGI89
  • CXorf11
  • DHHC9
  • MMSA1
  • MRXSZ
  • ZDHHC10
  • ZNF379
  • ZNF380