YEATS2 gene

YEATS domain containing 2

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

Summary: The protein encoded by this gene is a scaffolding subunit of the ATAC complex, which is a complex with acetyltransferase activity on histones H3 and H4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2017]

From UniProt:

Chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (PubMed:18838386, PubMed:19103755, PubMed:27103431). YEATS2 specifically recognizes and binds histone H3 crotonylated at 'Lys-27' (H3K27cr) (PubMed:27103431). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:27103431).

From NCBI Gene:

  • Epilepsy, familial adult myoclonic, 4

From UniProt:

Epilepsy, familial adult myoclonic, 4 (FAME4): A form of familial myoclonic epilepsy, a neurologic disorder characterized by cortical hand tremors, myoclonic jerks and occasional generalized or focal seizures with a non-progressive or very slowly progressive disease course. Usually, myoclonic tremor is the presenting symptom, characterized by tremulous finger movements and myoclonic jerks of the limbs increased by action and posture. In a minority of patients, seizures are the presenting symptom. Some patients exhibit mild cognitive impairment. FAME4 inheritance is autosomal dominant. [MIM:615127]

Cytogenetic Location: 3q27.1, which is the long (q) arm of chromosome 3 at position 27.1

Molecular Location: base pairs 183,697,797 to 183,812,625 on chromosome 3 (Homo sapiens Updated Annotation Release 109.20200522, GRCh38.p13) (NCBI)

Cytogenetic Location: 3q27.1, which is the long (q) arm of chromosome 3 at position 27.1