XRCC1 gene

X-ray repair cross complementing 1

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]

From UniProt:

Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.

From NCBI Gene:

  • SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 26

Cytogenetic Location: 19q13.31, which is the long (q) arm of chromosome 19 at position 13.31

Molecular Location: base pairs 43,543,312 to 43,575,578 on chromosome 19 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 19q13.31, which is the long (q) arm of chromosome 19 at position 13.31
  • RCC
  • SCAR26