XPNPEP2 gene

X-prolyl aminopeptidase 2

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

Aminopeptidase P is a hydrolase specific for N-terminal imido bonds, which are common to several collagen degradation products, neuropeptides, vasoactive peptides, and cytokines. Structurally, the enzyme is a member of the 'pita bread fold' family and occurs in mammalian tissues in both soluble and GPI-anchored membrane-bound forms. A membrane-bound and soluble form of this enzyme have been identified as products of two separate genes. [provided by RefSeq, Jul 2008]

From UniProt:

A metalloprotease that may play a role in the inflammatory process and other reactions produced in response to injury or infection. May also play a role in the metabolism of the vasodilator bradykinin.

From NCBI Gene:

  • Angioedema induced by ACE inhibitors, susceptibility to

From UniProt:

Angioedema induced by ACE inhibitors (AEACEI): A potentially life-threatening side effect of ACE inhibitors that appears in a subset of patients taking these drugs for hypertension and cardiovascular disease treatment. AEACEI is characterized by swelling of the face, lips, tongue, and airway that can lead to suffocation and death if severe. [MIM:300909]

Cytogenetic Location: Xq26.1, which is the long (q) arm of the X chromosome at position 26.1

Molecular Location: base pairs 129,738,970 to 129,769,549 on the X chromosome (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: Xq26.1, which is the long (q) arm of the X chromosome at position 26.1
  • AEACEI
  • APP2