WDFY3 gene

WD repeat and FYVE domain containing 3

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a phosphatidylinositol 3-phosphate-binding protein that functions as a master conductor for aggregate clearance by autophagy. This protein shuttles from the nuclear membrane to colocalize with aggregated proteins, where it complexes with other autophagic components to achieve macroautophagy-mediated clearance of these aggregated proteins. However, it is not necessary for starvation-induced macroautophagy. [provided by RefSeq, May 2010]

From UniProt:

Required for selective autophagy (aggrephagy) but not for autophagic degradation of bulk cytospol in response to starvation. Involved in the formation and degradation of cytoplasmic polyubiquitin-containing bodies (p62 bodies, ALIS/aggresome-like induced structures). May play a role as adaptor or scaffolding protein by promoting the association of the E3-like ligase ATG12-ATG5-ATG16L and LC3 to ubiquitinated target substrate. The association with GABARAP is required for its recruitment to LC3B-positive p62 bodies suggesting a role in targeting certain p62 structures for clearance. Involved in midbody ring degradation.

From NCBI Gene:

  • Microcephaly 18, primary, autosomal dominant

Cytogenetic Location: 4q21.23, which is the long (q) arm of chromosome 4 at position 21.23

Molecular Location: base pairs 84,669,537 to 84,966,391 on chromosome 4 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 4q21.23, which is the long (q) arm of chromosome 4 at position 21.23
  • ALFY
  • BCHS
  • MCPH18
  • ZFYVE25