VEGFC gene

vascular endothelial growth factor C

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. The encoded protein promotes angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. The proprotein is further cleaved into a fully processed form that can bind and activate VEGFR-2 and VEGFR-3 receptors. [provided by RefSeq, Apr 2014]

From UniProt:

Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors.

From NCBI Gene:

  • Lymphedema, hereditary, ID

From UniProt:

Lymphedema, hereditary, 1D (LMPH1D): A chronic disabling condition which results in swelling of the extremities due to altered lymphatic flow. Patients with lymphedema suffer from recurrent local infections and physical impairment. [MIM:615907]

Cytogenetic Location: 4q34.3, which is the long (q) arm of chromosome 4 at position 34.3

Molecular Location: base pairs 176,683,534 to 176,792,745 on chromosome 4 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 4q34.3, which is the long (q) arm of chromosome 4 at position 34.3
  • Flt4-L
  • LMPH1D
  • VRP