ubiquitin specific peptidase 9, Y-linked
The USP9Y gene provides instructions for making a protein called ubiquitin-specific protease 9. This gene is found on the Y chromosome. People normally have 46 chromosomes in each cell. Two of the 46 chromosomes are sex chromosomes, called X and Y. Females have two X chromosomes (46,XX), and males have one X chromosome and one Y chromosome (46,XY).
Because it is located on the Y chromosome, the USP9Y gene is present only in males. It occurs in a region of the Y chromosome called azoospermia factor A (AZFA). Azoospermia is the absence of sperm cells. The USP9Y gene is believed to be involved in sperm cell development, but its specific function is not well understood.
A small number of individuals with Y chromosome infertility have mutations in the USP9Y gene or deletions of all or part of the gene. These changes in the USP9Y gene prevent the production of ubiquitin-specific protease 9 or result in the production of an abnormally short, nonfunctional protein. The absence of functional ubiquitin-specific protease 9 impairs the production of sperm cells, resulting in an inability to father children.
- azoospermia factor 1
- deubiquitinating enzyme FAF-Y
- fat facets protein related, Y-linked
- ubiquitin specific peptidase 9, Y-linked (fat facets-like, Drosophila)
- ubiquitin-specific processing protease FAF-Y
- ubiquitin specific protease 9, Y chromosome (fat facets-like Drosophila)
- ubiquitin specific protease 9, Y-linked
- ubiquitin thiolesterase FAF-Y