USF1 gene

upstream transcription factor 1

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. This gene has been linked to familial combined hyperlipidemia (FCHL). Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been defined on chromosome 21. [provided by RefSeq, Feb 2013]

From UniProt:

Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters.

From NCBI Gene:

  • Hyperlipidemia, combined, 1

From UniProt:

Hyperlipidemia combined 1 (HYPLIP1): A disorder characterized by a variable pattern of elevated levels of serum total cholesterol, triglycerides or both. It is observed in a percentage of individuals with premature coronary heart disease. [MIM:602491]

Cytogenetic Location: 1q23.3, which is the long (q) arm of chromosome 1 at position 23.3

Molecular Location: base pairs 161,039,251 to 161,045,979 on chromosome 1 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 1q23.3, which is the long (q) arm of chromosome 1 at position 23.3
  • bHLHb11
  • FCHL
  • FCHL1
  • HYPLIP1
  • MLTF
  • MLTFI
  • UEF