UPK3A

uroplakin 3A

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a member of the uroplakin family, a group of transmembrane proteins that form complexes on the apical surface of the bladder epithelium. Mutations in this gene may be associated with renal adysplasia. Alternatively spliced transcript variants have been described.[provided by RefSeq, Nov 2009]

From UniProt:

Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence.

From UniProt:

Mutations in UPK3A have been detected in patients with renal adyplasia suggesting a possible involvement of this gene in kidney and urinary tract anomalies.

Cytogenetic Location: 22q13.31, which is the long (q) arm of chromosome 22 at position 13.31

Molecular Location: base pairs 45,284,987 to 45,295,874 on chromosome 22 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 22q13.31, which is the long (q) arm of chromosome 22 at position 13.31
  • UP3A
  • UPIII
  • UPIIIA
  • UPK3