ULBP3 gene

UL16 binding protein 3

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The protein encoded by this gene is one of several related ligands of the KLRK1/NKG2D receptor, which is found in primary NK cells. Binding of these ligands to the receptor activates several signal transduction pathways, including the JAK2, STAT5, and ERK pathways. The encoded protein is expressed solubly and on the surface of many tumor cells, making it potentially an important target for therapeutics. [provided by RefSeq, Nov 2015]

From UniProt:

Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.

Cytogenetic Location: 6q25.1, which is the long (q) arm of chromosome 6 at position 25.1

Molecular Location: base pairs 150,061,046 to 150,069,147 on chromosome 6 (Homo sapiens Annotation Release 109, GRCh38.p12) (NCBI)

Cytogenetic Location: 6q25.1, which is the long (q) arm of chromosome 6 at position 25.1
  • N2DL-3
  • NKG2DL3
  • RAET1N