UGT2B17

UDP glucuronosyltransferase family 2 member B17

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a member of the uridine diphosphoglucuronosyltransferase protein family. The encoded enzyme catalyzes the transfer of glucuronic acid from uridine diphosphoglucuronic acid to a diverse array of substrates including steroid hormones and lipid-soluble drugs. This process, known as glucuronidation, is an intermediate step in the metabolism of steroids. Copy number variation in this gene is associated with susceptibility to osteoporosis.[provided by RefSeq, Apr 2010]

From UniProt:

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. The major substrates of this isozyme are eugenol > 4-methylumbelliferone > dihydrotestosterone (DHT) > androstane-3-alpha,17-beta-diol (3-alpha-diol) > testosterone > androsterone (ADT).

From NCBI Gene:

  • Bone mineral density quantitative trait locus 12

Cytogenetic Location: 4q13, which is the long (q) arm of chromosome 4 at position 13

Molecular Location: base pairs 68,537,184 to 68,568,527 on chromosome 4 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 4q13, which is the long (q) arm of chromosome 4 at position 13
  • BMND12
  • UDPGT2B17