TUSC3 gene

tumor suppressor candidate 3

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a protein that has been associated with several biological functions including cellular magnesium uptake, protein glycosylation and embryonic development. This protein localizes to the endoplasmic reticulum and acts as a component of the oligosaccharyl transferase complex which is responsible for N-linked protein glycosylation. This gene is a candidate tumor suppressor gene. Homozygous mutations in this gene are associated with autosomal recessive nonsyndromic mental retardation-7 and in the proliferation and invasiveness of several cancers including metastatic pancreatic cancer, ovarian cancer and glioblastoma multiform. [provided by RefSeq, Oct 2017]

From UniProt:

Magnesium transporter.

Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Involved in N-glycosylation of STT3B-dependent substrates. Specifically required for the glycosylation of a subset of acceptor sites that are near cysteine residues; in this function seems to act redundantly with MAGT1. In its oxidized form proposed to form transient mixed disulfides with a glycoprotein substrate to facilitate access of STT3B to the unmodified acceptor site. Has also oxidoreductase-independent functions in the STT3B-containing OST complex possibly involving substrate recognition.

From NCBI Gene:

  • Mental retardation, autosomal recessive 7

From UniProt:

Mental retardation, autosomal recessive 7 (MRT7): A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. [MIM:611093]

Cytogenetic Location: 8p22, which is the short (p) arm of chromosome 8 at position 22

Molecular Location: base pairs 15,540,087 to 15,766,649 on chromosome 8 (Homo sapiens Updated Annotation Release 109.20200522, GRCh38.p13) (NCBI)

Cytogenetic Location: 8p22, which is the short (p) arm of chromosome 8 at position 22
  • D8S1992
  • M33
  • MagT2
  • MRT7
  • MRT22
  • N33
  • OST3A
  • SLC58A2