TUB gene

tubby bipartite transcription factor

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a member of the Tubby family of bipartite transcription factors. The encoded protein may play a role in obesity and sensorineural degradation. The crystal structure has been determined for a similar protein in mouse, and it functions as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

From UniProt:

Functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to membranes containing phosphatidylinositol 4,5-bisphosphate. Can bind DNA (in vitro). May contribute to the regulation of transcription in the nucleus. Could be involved in the hypothalamic regulation of body weight (By similarity). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages.

From NCBI Gene:

  • Retinal dystrophy and obesity

From UniProt:

Retinal dystrophy and obesity (RDOB): A disease characterized by obesity, night blindness, decreased visual acuity, and electrophysiological features of a rod cone dystrophy. [MIM:616188]

Cytogenetic Location: 11p15.4, which is the short (p) arm of chromosome 11 at position 15.4

Molecular Location: base pairs 8,019,180 to 8,106,107 on chromosome 11 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 11p15.4, which is the short (p) arm of chromosome 11 at position 15.4
  • rd5
  • RDOB