transient receptor potential cation channel subfamily M member 1
The TRPM1 gene provides instructions for making a protein called transient receptor potential cation channel subfamily M member 1 (TRPM1). This protein acts as a channel, transporting positively charged atoms (cations) into cells. The TRPM1 channel is found on the surface of two types of cells: pigment-producing cells called melanocytes and specialized bipolar cells in the light-sensitive tissue at the back of the eye (the retina).
In melanocytes, the TRPM1 channel is thought to play a role in the production of a pigment called melanin, which is the substance that gives skin, hair, and eyes their color (pigmentation). It is unclear what role the channel plays, but increased channel activity is associated with greater melanin production and darker pigmentation.
In bipolar cells, TRPM1 channels are involved in the pathway that receives visual signals from cells called rods, which are used to see in low light. This signaling is an essential step in the transmission of visual information from the eyes to the brain. In low-light conditions, visual signals from rod cells trigger the TRPM1 channels to close, which causes visual signals to be transmitted. In bright-light conditions, the TRPM1 channel is open, allowing cations to flow in and out of bipolar cells and preventing visual signals from being sent.
More than 35 mutations in the TRPM1 gene have been found to cause autosomal recessive congenital stationary night blindness, which is characterized by the inability to see in low light and other vision problems such as nearsightedness (myopia). Mutations in the TRPM1 gene are found in approximately half of all people with this condition.
Most TRPM1 gene mutations change single protein building blocks (amino acids) in the TRPM1 channel and either alter the structure of the channel or prevent the channel from reaching the bipolar cell membrane. As a result, the TRPM1 channel is nonfunctional and prevents bipolar cells from relaying visual signals. The brain does not receive the visual information sent by rods, leading to difficulty seeing in low light.
- long transient receptor potential channel 1
- transient receptor potential cation channel, subfamily M, member 1
- transient receptor potential melastatin family
- Madame Curie Bioscience Database: The TRP Family of Channel Proteins
- TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades (2007): TRP Superfamily Genes and Their Gene Products
- Webvision: The Organization of the Retina and Visual System: Retinal Processing: Bipolar Cells and the Photopic and Scotopic Pathways