TRMT5 gene

tRNA methyltransferase 5

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

tRNAs contain as many as 13 or 14 nucleotides that are modified posttranscriptionally by enzymes that are highly specific for particular nucleotides in the tRNA structure. TRMT5 methylates the N1 position of guanosine-37 (G37) in selected tRNAs using S-adenosyl methionine (Brule et al., 2004 [PubMed 15248782]).[supplied by OMIM, Mar 2008]

From UniProt:

Involved in mitochondrial tRNA methylation (PubMed:26189817). Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.

From NCBI Gene:

  • Combined oxidative phosphorylation deficiency 26

From UniProt:

Combined oxidative phosphorylation deficiency 26 (COXPD26): A mitochondrial disorder characterized by lactic acidosis, multiple mitochondrial respiratory-chain-complex deficiencies in skeletal muscle, and additional variable features including hypertrophic cardiomyopathy, exercise intolerance, and failure to thrive. [MIM:616539]

Cytogenetic Location: 14q23.1, which is the long (q) arm of chromosome 14 at position 23.1

Molecular Location: base pairs 60,971,441 to 60,981,170 on chromosome 14 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 14q23.1, which is the long (q) arm of chromosome 14 at position 23.1
  • COXPD26
  • KIAA1393
  • TRM5