TRMT1 gene

tRNA methyltransferase 1

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a tRNA-modifying enzyme that acts as a dimethyltransferase, modifying a single guanine residue at position 26 of the tRNA. The encoded enzyme has both mono- and dimethylase activity when exogenously expressed, and uses S-adenosyl methionine as a methyl donor. The C-terminal region of the encoded protein has both a zinc finger motif, and an arginine/proline-rich region. Mutations in this gene have been implicated in autosomal recessive intellectual disorder (ARID). Alternative splicing results in multiple transcript variants encoding different isoforms. There is a pseudogene of this gene on the X chromosome. [provided by RefSeq, May 2017]

From UniProt:

Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

From NCBI Gene:

  • INTELLECTUAL DEVELOPMENTAL DISORDER, AUTOSOMAL RECESSIVE 68

Cytogenetic Location: 19p13.13, which is the short (p) arm of chromosome 19 at position 13.13

Molecular Location: base pairs 13,104,900 to 13,117,567 on chromosome 19 (Homo sapiens Annotation Release 109, GRCh38.p12) (NCBI)

Cytogenetic Location: 19p13.13, which is the short (p) arm of chromosome 19 at position 13.13
  • MRT68
  • TRM1