TRIT1 gene

tRNA isopentenyltransferase 1

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a protein that that is targeted to the mitochondrion and modifies transfer RNAs (tRNAs) by adding a dimethylallyl group onto the adenine at position 37. This modification is important for maintaining the correct reading frame during protein translation. This gene is considered a tumor suppressor and its expression can decrease cell growth. Alternative splicing results in multiple transcripts variants, most of which are likely non-functional. [provided by RefSeq, Aug 2015]

From UniProt:

Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).

From NCBI Gene:

  • COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 35

From UniProt:

Combined oxidative phosphorylation deficiency 35 (COXPD35): An autosomal recessive disorder caused by defective mitochondrial metabolism and deficiencies of mitochondrial respiratory enzyme complexes. Clinical manifestations include global developmental delay, intellectual disability, microcephaly, and early-onset seizures. [MIM:617873]

Cytogenetic Location: 1p34.2, which is the short (p) arm of chromosome 1 at position 34.2

Molecular Location: base pairs 39,841,031 to 39,883,511 on chromosome 1 (Homo sapiens Annotation Release 109, GRCh38.p12) (NCBI)

Cytogenetic Location: 1p34.2, which is the short (p) arm of chromosome 1 at position 34.2
  • COXPD35
  • GRO1
  • hGRO1
  • IPPT
  • IPT
  • IPTase
  • MOD5