TRIB1 gene

tribbles pseudokinase 1

The information on this page was automatically extracted from online scientific databases.

From UniProt:

Adapter protein involved in protein degradation by interacting with RFWD2/COP1 ubiquitin ligase (PubMed:27041596). The RFWD2-binding motif is masked by autoinhibitory interactions with the protein kinase domain (PubMed:26455797). Serves to alter RFWD2 substrate specificity by directing the activity of RFWD2 toward CEBPA (PubMed:27041596). Binds selectively the recognition sequence of CEBPA (PubMed:26455797). Regulates myeloid cell differentiation by altering the expression of CEBPA in a RFWD2-dependent manner (By similarity). Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain (By similarity). Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity (PubMed:15299019, PubMed:26455797).

Cytogenetic Location: 8q24.13, which is the long (q) arm of chromosome 8 at position 24.13

Molecular Location: base pairs 125,430,100 to 125,438,405 on chromosome 8 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 8q24.13, which is the long (q) arm of chromosome 8 at position 24.13
  • C8FW
  • GIG-2
  • GIG2
  • SKIP1
  • TRB-1
  • TRB1