TRHR gene

thyrotropin releasing hormone receptor

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a G protein-coupled receptor for thyrotropin-releasing hormone (TRH). Upon binding to TRH, this receptor activates the inositol phospholipid-calcium-protein kinase C transduction pathway. Mutations in this gene have been associated with generalized thyrotropin-releasing hormone resistance. [provided by RefSeq, Sep 2011]

From UniProt:

Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.

Covered on Genetics Home Reference:

From NCBI Gene:

  • HYPOTHYROIDISM, CONGENITAL, NONGOITROUS, 7

From UniProt:

Hypothyroidism, congenital, non-goitrous, 7 (CHNG7): A form of central hypothyroidism, a disorder characterized by sub-optimal thyroid hormone secretion, due to insufficient stimulation by thyrotropin of an otherwise normal thyroid gland. It may be caused by congenital or acquired disorders of the pituitary gland or hypothalamus. CHNG7 is a congenital, autosomal recessive form characterized by normal-to-low T4 and normal-to-high thyrotropin levels, and reduced or absent pituitary responsiveness to thyrotropin-releasing hormone. Patients may exhibit short stature, growth retardation, and delayed bone age, as well as lethargy or fatigue. [MIM:618573]

Cytogenetic Location: 8q23.1, which is the long (q) arm of chromosome 8 at position 23.1

Molecular Location: base pairs 109,086,585 to 109,121,565 on chromosome 8 (Homo sapiens Updated Annotation Release 109.20200522, GRCh38.p13) (NCBI)

Cytogenetic Location: 8q23.1, which is the long (q) arm of chromosome 8 at position 23.1
  • CHNG7
  • TRH-R