TPH2 gene

tryptophan hydroxylase 2

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression. [provided by RefSeq, Feb 2016]

From NCBI Gene:

  • Attention deficit-hyperactivity disorder 7
  • Major depressive disorder

From UniProt:

Major depressive disorder (MDD): A common psychiatric disorder. It is a complex trait characterized by one or more major depressive episodes without a history of manic, mixed, or hypomanic episodes. A major depressive episode is characterized by at least 2 weeks during which there is a new onset or clear worsening of either depressed mood or loss of interest or pleasure in nearly all activities. Four additional symptoms must also be present including changes in appetite, weight, sleep, and psychomotor activity; decreased energy; feelings of worthlessness or guilt; difficulty thinking, concentrating, or making decisions; or recurrent thoughts of death or suicidal ideation, plans, or attempts. The episode must be accompanied by distress or impairment in social, occupational, or other important areas of functioning. [MIM:608516]

Attention deficit-hyperactivity disorder 7 (ADHD7): A neurobehavioral developmental disorder primarily characterized by the coexistence of attentional problems and hyperactivity, with each behavior occurring infrequently alone. [MIM:613003]

Cytogenetic Location: 12q21.1, which is the long (q) arm of chromosome 12 at position 21.1

Molecular Location: base pairs 71,938,845 to 72,032,440 on chromosome 12 (Homo sapiens Updated Annotation Release 109.20200522, GRCh38.p13) (NCBI)

Cytogenetic Location: 12q21.1, which is the long (q) arm of chromosome 12 at position 21.1
  • ADHD7
  • NTPH