TOP2B gene

DNA topoisomerase II beta

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]

From UniProt:

Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.

From UniProt:

A defect in TOP2B is associated with autism spectrum disorder (ASD).

Cytogenetic Location: 3p24.2, which is the short (p) arm of chromosome 3 at position 24.2

Molecular Location: base pairs 25,597,905 to 25,664,891 on chromosome 3 (Homo sapiens Annotation Release 109, GRCh38.p12) (NCBI)

Cytogenetic Location: 3p24.2, which is the short (p) arm of chromosome 3 at position 24.2
  • top2beta