TNRC6A gene

trinucleotide repeat containing adaptor 6A

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a member of the trinucleotide repeat containing 6 protein family. The protein functions in post-transcriptional gene silencing through the RNA interference (RNAi) and microRNA pathways. The protein associates with messenger RNAs and Argonaute proteins in cytoplasmic bodies known as GW-bodies or P-bodies. Inhibiting expression of this gene delocalizes other GW-body proteins and impairs RNAi and microRNA-induced gene silencing. [provided by RefSeq, Jul 2008]

From UniProt:

Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As a scaffolding protein, associates with argonaute proteins bound to partially complementary mRNAs, and can simultaneously recruit CCR4-NOT and PAN deadenylase complexes.

From NCBI Gene:

  • EPILEPSY, FAMILIAL ADULT MYOCLONIC, 6

From UniProt:

Epilepsy, familial adult myoclonic, 6 (FAME6): A form of familial myoclonic epilepsy, a neurologic disorder characterized by cortical hand tremors, myoclonic jerks and occasional generalized or focal seizures with a non-progressive or very slowly progressive disease course. Usually, myoclonic tremor is the presenting symptom, characterized by tremulous finger movements and myoclonic jerks of the limbs increased by action and posture. In a minority of patients, seizures are the presenting symptom. Some patients exhibit mild cognitive impairment. FAME6 inheritance is autosomal dominant. [MIM:618074]

Cytogenetic Location: 16p12.1, which is the short (p) arm of chromosome 16 at position 12.1

Molecular Location: base pairs 24,610,205 to 24,826,223 on chromosome 16 (Homo sapiens Updated Annotation Release 109.20190905, GRCh38.p13) (NCBI)

Cytogenetic Location: 16p12.1, which is the short (p) arm of chromosome 16 at position 12.1
  • CAGH26
  • FAME6
  • GW1
  • GW182
  • TNRC6