TNRC6A gene

trinucleotide repeat containing 6A

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a member of the trinucleotide repeat containing 6 protein family. The protein functions in post-transcriptional gene silencing through the RNA interference (RNAi) and microRNA pathways. The protein associates with messenger RNAs and Argonaute proteins in cytoplasmic bodies known as GW-bodies or P-bodies. Inhibiting expression of this gene delocalizes other GW-body proteins and impairs RNAi and microRNA-induced gene silencing. [provided by RefSeq, Jul 2008]

From UniProt:

Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As a scaffolding protein, associates with argonaute proteins bound to partially complementary mRNAs, and can simultaneously recruit CCR4-NOT and PAN deadenylase complexes.

Cytogenetic Location: 16p12.1, which is the short (p) arm of chromosome 16 at position 12.1

Molecular Location: base pairs 24,610,209 to 24,826,227 on chromosome 16 (Homo sapiens Annotation Release 109, GRCh38.p12) (NCBI)

Cytogenetic Location: 16p12.1, which is the short (p) arm of chromosome 16 at position 12.1
  • CAGH26
  • FAME6
  • GW1
  • GW182
  • TNRC6