TNFSF4 gene

tumor necrosis factor superfamily member 4

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a cytokine of the tumor necrosis factor (TNF) ligand family. The encoded protein functions in T cell antigen-presenting cell (APC) interactions and mediates adhesion of activated T cells to endothelial cells. Polymorphisms in this gene have been associated with Sjogren's syndrome and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

From UniProt:

Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.

Covered on Genetics Home Reference:

From NCBI Gene:

  • Myocardial infarction 1

From UniProt:

Systemic lupus erythematosus (SLE): A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. [MIM:152700]

Cytogenetic Location: 1q25, which is the long (q) arm of chromosome 1 at position 25

Molecular Location: base pairs 173,183,729 to 173,462,208 on chromosome 1 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 1q25, which is the long (q) arm of chromosome 1 at position 25
  • CD134L
  • CD252
  • GP34
  • OX-40L
  • OX4OL
  • TNLG2B
  • TXGP1