TNFRSF4 gene

TNF receptor superfamily member 4

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008]

From UniProt:

Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity.

(Microbial infection) Acts as a receptor for human herpesvirus 6B/HHV-6B.

From NCBI Gene:

  • Immunodeficiency 16

From UniProt:

Immunodeficiency 16 (IMD16): An autosomal recessive primary immunodeficiency associated with classic Kaposi sarcoma of childhood and poor T-cell recall immune responses due to complete functional OX40 deficiency. [MIM:615593]

Cytogenetic Location: 1p36, which is the short (p) arm of chromosome 1 at position 36

Molecular Location: base pairs 1,211,326 to 1,216,812 on chromosome 1 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 1p36, which is the short (p) arm of chromosome 1 at position 36
  • ACT35
  • CD134
  • IMD16
  • OX40
  • TXGP1L