TNFRSF14 gene

TNF receptor superfamily member 14

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a member of the TNF (tumor necrosis factor) receptor superfamily. The encoded protein functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. It binds herpes simplex virus (HSV) viral envelope glycoprotein D (gD), mediating its entry into cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

From UniProt:

Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells.

(Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 and herpes simplex virus 1/HHV-2.

Cytogenetic Location: 1p36.32, which is the short (p) arm of chromosome 1 at position 36.32

Molecular Location: base pairs 2,555,767 to 2,565,622 on chromosome 1 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 1p36.32, which is the short (p) arm of chromosome 1 at position 36.32
  • ATAR
  • CD270
  • HVEA
  • HVEM
  • LIGHTR
  • TR2