TNC gene

tenascin C

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration. [provided by RefSeq, Jul 2011]

From UniProt:

Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6.

Covered on Genetics Home Reference:

From NCBI Gene:

  • Deafness, autosomal dominant 56

From UniProt:

Deafness, autosomal dominant, 56 (DFNA56): A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNA56 is characterized by progressive hearing impairment with post-lingual onset. [MIM:615629]

Cytogenetic Location: 9q33.1, which is the long (q) arm of chromosome 9 at position 33.1

Molecular Location: base pairs 115,019,575 to 115,118,257 on chromosome 9 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 9q33.1, which is the long (q) arm of chromosome 9 at position 33.1
  • 150-225
  • DFNA56
  • GMEM
  • GP
  • HXB
  • JI
  • TN
  • TN-C