TMPRSS15 gene

transmembrane protease, serine 15

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes an enzyme that converts the pancreatic proenzyme trypsinogen to trypsin, which activates other proenzymes including chymotrypsinogen and procarboxypeptidases. The precursor protein is cleaved into two chains that form a heterodimer linked by a disulfide bond. This protein is a member of the trypsin family of peptidases. Mutations in this gene cause enterokinase deficiency, a malabsorption disorder characterized by diarrhea and failure to thrive. [provided by RefSeq, Jul 2008]

From UniProt:

Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases.

From NCBI Gene:

  • Enterokinase deficiency

From UniProt:

Enterokinase deficiency (ENTKD): Life-threatening intestinal malabsorption disorder characterized by diarrhea and failure to thrive. [MIM:226200]

Cytogenetic Location: 21q21.1, which is the long (q) arm of chromosome 21 at position 21.1

Molecular Location: base pairs 18,269,107 to 18,403,806 on chromosome 21 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 21q21.1, which is the long (q) arm of chromosome 21 at position 21.1
  • ENTK
  • PRSS7