TMPO gene

thymopoietin

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The protein encoded by this gene resides in the nucleus and may play a role in the assembly of the nuclear lamina, and thus help maintain the structural organization of the nuclear envelope. It may function as a receptor for the attachment of lamin filaments to the inner nuclear membrane. Mutations in this gene are associated with dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, May 2010]

From UniProt: LAP2A_HUMAN:

May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1.

TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide.

From UniProt: LAP2B_HUMAN:

Thymopoietin (TP) and Thymopentin (TP5) may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide.

May help direct the assembly of the nuclear lamina and thereby help maintain the structural organization of the nuclear envelope. Possible receptor for attachment of lamin filaments to the inner nuclear membrane. May be involved in the control of initiation of DNA replication through its interaction with NAKAP95.

Covered on Genetics Home Reference:

From NCBI Gene:

  • Dilated cardiomyopathy 1T

From UniProt: LAP2A_HUMAN:

Cardiomyopathy, dilated 1T (CMD1T): A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. [MIM:613740]

Cytogenetic Location: 12q23.1, which is the long (q) arm of chromosome 12 at position 23.1

Molecular Location: base pairs 98,515,573 to 98,550,379 on chromosome 12 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 12q23.1, which is the long (q) arm of chromosome 12 at position 23.1
  • CMD1T
  • LAP2
  • LEMD4
  • PRO0868
  • TP