TLK2 gene

tousled like kinase 2

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a nuclear serine/threonine kinase that was first identified in Arabidopsis. The encoded protein is thought to function in the regulation of chromatin assembly in the S phase of the cell cycle by regulating the levels of a histone H3/H4 chaperone. This protein is associated with double-strand break repair of DNA damage caused by radiation. Pseudogenes of this gene are present on chromosomes 10 and 17. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

From UniProt:

Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A AND ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy.

Cytogenetic Location: 17q23.2, which is the long (q) arm of chromosome 17 at position 23.2

Molecular Location: base pairs 62,470,908 to 62,615,481 on chromosome 17 (Homo sapiens Annotation Release 109, GRCh38.p12) (NCBI)

Cytogenetic Location: 17q23.2, which is the long (q) arm of chromosome 17 at position 23.2
  • HsHPK
  • MRD57
  • PKU-ALPHA