TLE3 gene

transducin like enhancer of split 3

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]

From UniProt:

Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES.

Cytogenetic Location: 15q23, which is the long (q) arm of chromosome 15 at position 23

Molecular Location: base pairs 70,047,790 to 70,097,935 on chromosome 15 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 15q23, which is the long (q) arm of chromosome 15 at position 23
  • ESG
  • ESG3
  • GRG3
  • HsT18976