TKFC gene

triokinase and FMN cyclase

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene is a member of the family of dihydroxyacetone kinases, which have a protein structure distinct from other kinases. The product of this gene phosphorylates dihydroxyacetone, and also catalyzes the formation of riboflavin 4',5'-phosphate (aka cyclin FMN) from FAD. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2017]

From UniProt:

Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate. Represses IFIH1-mediated cellular antiviral response (PubMed:17600090).

From NCBI Gene:

  • TRIOKINASE AND FMN CYCLASE DEFICIENCY SYNDROME

Cytogenetic Location: 11q12.2, which is the long (q) arm of chromosome 11 at position 12.2

Molecular Location: base pairs 61,333,182 to 61,353,426 on chromosome 11 (Homo sapiens Updated Annotation Release 109.20200522, GRCh38.p13) (NCBI)

Cytogenetic Location: 11q12.2, which is the long (q) arm of chromosome 11 at position 12.2
  • DAK
  • NET45
  • TKFCD