THSD7A gene

thrombospondin type 1 domain containing 7A

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The protein encoded by this gene is found almost exclusively in endothelial cells from placenta and umbilical cord. The encoded protein appears to interact with alpha(V)beta(3) integrin and paxillin to inhibit endothelial cell migration and tube formation. This protein may be involved in cytoskeletal organization. Variations in this gene may be associated with low bone mineral density in osteoporosis. [provided by RefSeq, Aug 2010]

From UniProt:

Thrombospondin type-1 domain-containing protein 7A, soluble form: The soluble form promotes endothelial cell migration and filopodia formation during sprouting angiogenesis via a FAK-dependent mechanism.

Thrombospondin type-1 domain-containing protein 7A: Plays a role in actin cytoskeleton rearrangement.

From UniProt:

Autoantibodies against THSD7A have been detected in serum and glomeruli from patients with idiopathic membranous nephropathy (PubMed:25394321). The majority of the autoantibodies react with the two most N-terminal TSP type-1 domains (PubMed:29555830).

Cytogenetic Location: 7p21.3, which is the short (p) arm of chromosome 7 at position 21.3

Molecular Location: base pairs 11,370,435 to 11,832,198 on chromosome 7 (Homo sapiens Annotation Release 109, GRCh38.p12) (NCBI)

Cytogenetic Location: 7p21.3, which is the short (p) arm of chromosome 7 at position 21.3