TF gene

transferrin

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. [provided by RefSeq, Sep 2009]

From UniProt:

Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.

From NCBI Gene:

  • Atransferrinemia

From UniProt:

Atransferrinemia (ATRAF): A rare autosomal recessive disorder characterized by abnormal synthesis of transferrin leading to iron overload and microcytic hypochromic anemia. [MIM:209300]

Cytogenetic Location: 3q22.1, which is the long (q) arm of chromosome 3 at position 22.1

Molecular Location: base pairs 133,661,998 to 133,779,006 on chromosome 3 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 3q22.1, which is the long (q) arm of chromosome 3 at position 22.1
  • HEL-S-71p
  • PRO1557
  • PRO2086
  • TFQTL1