TENM3 gene

teneurin transmembrane protein 3

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a large transmembrane protein that may be involved in the regulation of neuronal development. Mutation in this gene causes microphthalmia. [provided by RefSeq, Aug 2015]

From UniProt:

Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes axon guidance and homophilic cell adhesion. Plays a role in the development of the visual pathway; regulates the formation in ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC). May be involved in the differentiation of the fibroblast-like cells in the superficial layer of mandibular condylar cartilage into chondrocytes. May function as a cellular signal transducer.

From NCBI Gene:

  • Microphthalmia, isolated, with coloboma 9

From UniProt:

Microphthalmia, isolated, with coloboma, 9 (MCOPCB9): A disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, and other abnormalities may also be present. Ocular colobomas are a set of malformations resulting from abnormal morphogenesis of the optic cup and stalk, and the fusion of the fetal fissure (optic fissure). [MIM:615145]

Cytogenetic Location: 4q35.1, which is the long (q) arm of chromosome 4 at position 35.1

Molecular Location: base pairs 181,447,613 to 182,803,024 on chromosome 4 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 4q35.1, which is the long (q) arm of chromosome 4 at position 35.1
  • MCOPCB9
  • ODZ3
  • ten-3
  • Ten-m3
  • TNM3