TDO2 gene

tryptophan 2,3-dioxygenase

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism. [provided by RefSeq, Feb 2012]

From UniProt:

Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.

Cytogenetic Location: 4q32.1, which is the long (q) arm of chromosome 4 at position 32.1

Molecular Location: base pairs 155,903,693 to 155,920,406 on chromosome 4 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 4q32.1, which is the long (q) arm of chromosome 4 at position 32.1
  • HYPTRP
  • TDO
  • TO
  • TPH2
  • TRPO