TBXA2R gene

thromboxane A2 receptor

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a member of the G protein-coupled receptor family. The protein interacts with thromboxane A2 to induce platelet aggregation and regulate hemostasis. A mutation in this gene results in a bleeding disorder. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

From UniProt:

Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase.

From NCBI Gene:

  • Platelet-type bleeding disorder 13, susceptibility to

From UniProt:

Bleeding disorder, platelet-type 13 (BDPLT13): A disorder characterized by reduced platelet aggregation and a tendency to mild mucocutaneous bleeding. [MIM:614009]

Cytogenetic Location: 19p13.3, which is the short (p) arm of chromosome 19 at position 13.3

Molecular Location: base pairs 3,594,506 to 3,608,749 on chromosome 19 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 19p13.3, which is the short (p) arm of chromosome 19 at position 13.3
  • BDPLT13
  • TXA2-R