TBX21 gene

T-box 21

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq, Jul 2008]

From UniProt:

Transcription factor that controls the expression of the TH1 cytokine, interferon-gamma. Initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the opposing TH2 programs.

From NCBI Gene:

  • Asthma, nasal polyps, and aspirin intolerance

From UniProt:

Asthma, with nasal polyps and aspirin intolerance (ANPAI): A condition consisting of asthma, aspirin sensitivity and nasal polyposis. Nasal polyposis is due to chronic inflammation of the paranasal sinus mucosa, leading to protrusion of edematous polyps into the nasal cavities. [MIM:208550]

Cytogenetic Location: 17q21.32, which is the long (q) arm of chromosome 17 at position 21.32

Molecular Location: base pairs 47,733,240 to 47,746,122 on chromosome 17 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 17q21.32, which is the long (q) arm of chromosome 17 at position 21.32
  • T-bet
  • T-PET
  • TBET
  • TBLYM