TARS1 gene

threonyl-tRNA synthetase 1

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Threonyl-tRNA synthetase belongs to the class-II aminoacyl-tRNA synthetase family [provided by RefSeq, Jul 2008]

From UniProt:

Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) (PubMed:25824639). Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post-transfer stage (By similarity).

Cytogenetic Location: 5p13.3, which is the short (p) arm of chromosome 5 at position 13.3

Molecular Location: base pairs 33,440,696 to 33,468,091 on chromosome 5 (Homo sapiens Updated Annotation Release 109.20190905, GRCh38.p13) (NCBI)

Cytogenetic Location: 5p13.3, which is the short (p) arm of chromosome 5 at position 13.3
  • TARS
  • ThrRS
  • TTD7