TAF4B gene

TATA-box binding protein associated factor 4b

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

TATA binding protein (TBP) and TBP-associated factors (TAFs) participate in the formation of the TFIID protein complex, which is involved in initiation of transcription of genes by RNA polymerase II. This gene encodes a cell type-specific TAF that may be responsible for mediating transcription by a subset of activators in B cells. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]

From UniProt:

Cell type-specific subunit of the general transcription factor TFIID that may function as a gene-selective coactivator in certain cells. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TAF4B is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit. Involved in the activation of a subset of antiapoptotic genes including TNFAIP3. May be involved in regulating folliculogenesis. Through interaction with OCBA/POU2AF1, acts as a coactivator of B-cell-specific transcription. Plays a role in spermiogenesis and oogenesis.

From NCBI Gene:

  • Spermatogenic failure 13

From UniProt:

Spermatogenic failure 13 (SPGF13): A disorder resulting in the absence (azoospermia) or reduction (oligozoospermia) of sperm in the semen, leading to male infertility. [MIM:615841]

Cytogenetic Location: 18q11.2, which is the long (q) arm of chromosome 18 at position 11.2

Molecular Location: base pairs 26,226,491 to 26,391,685 on chromosome 18 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 18q11.2, which is the long (q) arm of chromosome 18 at position 11.2
  • SPGF13
  • TAF2C2
  • TAFII105