SULF1 gene

sulfatase 1

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes an extracellular heparan sulfate endosulfatase. The encoded enzyme selectively removes 6-O-sulfate groups from heparan sulfate chains of heparan sulfate proteoglycans (HSPGs). The enzyme is secreted through the Golgi and is subsequently localized to the cell surface. The expression of this gene may be down-regulated in several types of cancer, including hepatocellular (HCC), ovarian and breast cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

From UniProt:

Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin. Diminishes HSPG (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation.

Cytogenetic Location: 8q13.2-q13.3, which is the long (q) arm of chromosome 8 between positions 13.2 and 13.3

Molecular Location: base pairs 69,466,624 to 69,660,912 on chromosome 8 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 8q13.2-q13.3, which is the long (q) arm of chromosome 8 between positions 13.2 and 13.3
  • SULF-1