STS gene

steroid sulfatase (microsomal), isozyme S

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a multi-pass membrane protein that is localized to the endoplasmic reticulum. It belongs to the sulfatase family and hydrolyzes several 3-beta-hydroxysteroid sulfates, which serve as metabolic precursors for estrogens, androgens, and cholesterol. Mutations in this gene are associated with X-linked ichthyosis (XLI). Alternatively spliced transcript variants resulting from the use of different promoters have been described for this gene (PMID:17601726). [provided by RefSeq, Mar 2016]

From UniProt:

Conversion of sulfated steroid precursors to estrogens during pregnancy.

From NCBI Gene:

  • X-linked ichthyosis with steryl-sulfatase deficiency

From UniProt:

Ichthyosis, X-linked (IXL): A keratinization disorder manifesting with mild erythroderma and generalized exfoliation of the skin within a few weeks after birth. Affected boys later develop large, polygonal, dark brown scales, especially on the neck, extremities, trunk, and buttocks. [MIM:308100]

Cytogenetic Location: Xp22.31, which is the short (p) arm of the X chromosome at position 22.31

Molecular Location: base pairs 7,147,252 to 7,354,643 on the X chromosome (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: Xp22.31, which is the short (p) arm of the X chromosome at position 22.31
  • ARSC
  • ARSC1
  • ASC
  • ES
  • SSDD
  • XLI