SRGAP1 gene

SLIT-ROBO Rho GTPase activating protein 1

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The protein encoded by this gene is a GTPase activator, working with the GTPase CDC42 to negatively regulate neuronal migration. The encoded protein interacts with the transmembrane receptor ROBO1 to inactivate CDC42. [provided by RefSeq, Sep 2016]

From UniProt:

GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42.

From NCBI Gene:

  • Thyroid cancer, follicular

From UniProt:

Thyroid cancer, non-medullary, 2 (NMTC2): A form of non-medullary thyroid cancer (NMTC), a cancer characterized by tumors originating from the thyroid follicular cells. NMTCs represent approximately 95% of all cases of thyroid cancer and are classified into papillary, follicular, Hurthle cell, and anaplastic neoplasms. [MIM:188470]

Cytogenetic Location: 12q14.2, which is the long (q) arm of chromosome 12 at position 14.2

Molecular Location: base pairs 63,844,372 to 64,147,863 on chromosome 12 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 12q14.2, which is the long (q) arm of chromosome 12 at position 14.2
  • ARHGAP13
  • NMTC2