SRA1 gene

steroid receptor RNA activator 1

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

Both long non-coding and protein-coding RNAs are transcribed from this gene, and they represent alternatively spliced transcript variants. This gene was initially defined as a non-coding RNA, which is a coactivator for several nuclear receptors (NRs) and is associated with breast cancer. It has now been found that this gene is involved in the regulation of many NR and non-NR activities, including metabolism, adipogenesis and chromatin organization. The long non-coding RNA transcripts interact with a variety of proteins, including the protein encoded by this gene. The encoded protein acts as a transcriptional repressor by binding to the non-coding RNA. [provided by RefSeq, Mar 2012]

From UniProt:

Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis.

From NCBI Gene:

  • Hypogonadotropic hypogonadism 7 with or without anosmia

Cytogenetic Location: 5q31.3, which is the long (q) arm of chromosome 5 at position 31.3

Molecular Location: base pairs 140,550,067 to 140,558,093 on chromosome 5 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 5q31.3, which is the long (q) arm of chromosome 5 at position 31.3
  • pp7684
  • SRA
  • SRAP
  • STRAA1