SPARC gene

secreted protein acidic and cysteine rich

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2015]

From UniProt:

Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.

From NCBI Gene:

  • Osteogenesis imperfecta, type xvii

From UniProt:

Osteogenesis imperfecta 17 (OI17): An autosomal recessive form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. [MIM:616507]

Cytogenetic Location: 5q31.3-q32, which is the long (q) arm of chromosome 5 between positions 31.3 and 32

Molecular Location: base pairs 151,661,096 to 151,687,054 on chromosome 5 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 5q31.3-q32, which is the long (q) arm of chromosome 5 between positions 31.3 and 32
  • BM-40
  • OI17
  • ON