SOD2 gene

superoxide dismutase 2, mitochondrial

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. [provided by RefSeq, Apr 2016]

From UniProt:

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

From NCBI Gene:

  • Microvascular complications of diabetes 6

From UniProt:

Microvascular complications of diabetes 6 (MVCD6): Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. [MIM:612634]

Cytogenetic Location: 6q25.3, which is the long (q) arm of chromosome 6 at position 25.3

Molecular Location: base pairs 159,679,064 to 159,762,529 on chromosome 6 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 6q25.3, which is the long (q) arm of chromosome 6 at position 25.3
  • IPO-B
  • IPOB
  • Mn-SOD
  • MNSOD
  • MVCD6